Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking
Overconsumption of palatable food may initiate neuroadaptive responses in brain reward
circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) …
circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) …
[HTML][HTML] Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
LE Linders, L Patrikiou, M Soiza-Reilly… - Nature …, 2022 - nature.com
Stress can cause overconsumption of palatable high caloric food. Despite the important role
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …
[HTML][HTML] Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating
Food is a powerful natural reinforcer that guides feeding decisions. The vagus nerve
conveys internal sensory information from the gut to the brain about nutritional value; …
conveys internal sensory information from the gut to the brain about nutritional value; …
[HTML][HTML] Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and
occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that …
occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that …
Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids
The prevalence of obesity has markedly increased over the past few decades. Exploration of
how hunger and satiety signals influence the reward system can help us understand non …
how hunger and satiety signals influence the reward system can help us understand non …
Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum
TM Furlong, HK Jayaweera, BW Balleine… - Journal of …, 2014 - Soc Neuroscience
Access to highly palatable and calorically dense foods contributes to increasing rates of
obesity worldwide. Some have made the controversial argument that consumption of such …
obesity worldwide. Some have made the controversial argument that consumption of such …
A neural circuit for excessive feeding driven by environmental context in mice
Despite notable genetic influences, obesity mainly results from the overconsumption of food,
which arises from the interplay of physiological, cognitive and environmental factors. In …
which arises from the interplay of physiological, cognitive and environmental factors. In …
Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal
Objective: To identify the emotional and motivational processes that reinstate palatable food
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …
[HTML][HTML] Sucrose consumption alters serotonin/glutamate co-localisation within the prefrontal cortex and hippocampus of mice
The overconsumption of sugar-sweetened food and beverages underpins the current rise in
obesity rates. Sugar overconsumption induces maladaptive neuroplasticity to decrease …
obesity rates. Sugar overconsumption induces maladaptive neuroplasticity to decrease …
Consumption of palatable food primes food approach behavior by rapidly increasing synaptic density in the VTA
In an environment with easy access to highly palatable and energy-dense food, food-related
cues drive food-seeking regardless of satiety, an effect that can lead to obesity. The ventral …
cues drive food-seeking regardless of satiety, an effect that can lead to obesity. The ventral …