[HTML][HTML] Model for the peptide-free conformation of class II MHC proteins
Background Major histocompatibility complex proteins are believed to undergo significant
conformational changes concomitant with peptide binding, but structural characterization of …
conformational changes concomitant with peptide binding, but structural characterization of …
A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules
MG Mage, MA Dolan, R Wang, LF Boyd… - Molecular …, 2013 - Elsevier
The mature conformation of major histocompatibility complex class I (MHC-I) proteins
depends on the presence of bound peptides, permitting recognition at the cell surface by …
depends on the presence of bound peptides, permitting recognition at the cell surface by …
Conformational variation in structures of classical and non‐classical MHCII proteins and functional implications
CA Painter, LJ Stern - Immunological reviews, 2012 - Wiley Online Library
Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …
Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study
R Yaneva, S Springer… - … : Original Research on …, 2009 - Wiley Online Library
Abstract Major histocompatibility (MHC) Class II cell surface proteins present antigenic
peptides to the immune system. Class II structures in complex with peptides but not in the …
peptides to the immune system. Class II structures in complex with peptides but not in the …
[HTML][HTML] Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection
R Anjanappa, M Garcia-Alai, JD Kopicki… - Nature …, 2020 - nature.com
Abstract Major Histocompatibility Complex (MHC) class I molecules selectively bind
peptides for presentation to cytotoxic T cells. The peptide-free state of these molecules is not …
peptides for presentation to cytotoxic T cells. The peptide-free state of these molecules is not …
[HTML][HTML] The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and …
Major histocompatibility complex (MHC) class I molecules (proteins) bind peptides of eight to
ten amino acids to present them at the cell surface to cytotoxic T cells. The class I binding …
ten amino acids to present them at the cell surface to cytotoxic T cells. The class I binding …
[PDF][PDF] Conformational flexibility of the MHC class I α1-α2 domain in peptide bound and free states: a molecular dynamics simulation study
M Zacharias, S Springer - Biophysical journal, 2004 - cell.com
Major histocompatibility complex class I proteins play a key role in the recognition and
presentation of peptide antigens to the host immune system. The structure of various major …
presentation of peptide antigens to the host immune system. The structure of various major …
Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein
The complexity of the interaction between major histocompatibility complex class II (MHC II)
proteins and peptide ligands has been revealed through structural studies and …
proteins and peptide ligands has been revealed through structural studies and …
Changes at the floor of the peptide‐binding groove induce a strong preference for Proline at position 3 of the bound peptide: Molecular dynamics simulations of HLA …
H Toh, CJ Savoie, N Kamikawaji, S Muta… - Biopolymers …, 2000 - Wiley Online Library
We report on molecular dynamics simulations of major histocompatibility complex (MHC)–
peptide complexes. Class I MHC molecules play an important role in cellular immunity by …
peptide complexes. Class I MHC molecules play an important role in cellular immunity by …
Crystal structures of HLA‐A* 0201 complexed with antigenic peptides with either the amino‐or carboxyl‐terminal group substituted by a methyl group
M Bouvier, HC Guo, KJ Smith… - … : Structure, Function, and …, 1998 - Wiley Online Library
The crystal structures of class I major histocompatibility complex (MHC) molecules
complexed with antigenic peptides revealed a network of hydrogen bonds between the …
complexed with antigenic peptides revealed a network of hydrogen bonds between the …