m6A modulates haematopoietic stem and progenitor cell specification
C Zhang, Y Chen, B Sun, LU Wang, Y Yang, D Ma, J Lv… - Nature, 2017 - nature.com
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant modification
on eukaryote messenger RNA (mRNA). Although the rapid development of high-throughput …
on eukaryote messenger RNA (mRNA). Although the rapid development of high-throughput …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals
N6-methyladenosine (m6A) is one of the most abundant internal mRNA modifications, and it
affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites …
affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites …
The RNA N6-methyladenosine modification landscape of human fetal tissues
S Xiao, S Cao, Q Huang, L Xia, M Deng, M Yang… - Nature cell …, 2019 - nature.com
A single genome gives rise to diverse tissues through complex epigenomic mechanisms,
including N 6-methyladenosine (m6A), a widespread RNA modification that is implicated in …
including N 6-methyladenosine (m6A), a widespread RNA modification that is implicated in …
m6A RNA modification controls cell fate transition in mammalian embryonic stem cells
Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …
RNAs and is linked to human diseases, but its functions in mammalian development are …
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition
Y Wu, X Xu, M Qi, C Chen, M Li, R Yan, X Kou… - Nature cell …, 2022 - nature.com
Abstract N 6-methyladenosine (m6A) and its regulatory components play critical roles in
various developmental processes in mammals. However, the landscape and function of …
various developmental processes in mammals. However, the landscape and function of …
Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation
Haematopoietic stem cells (HSCs) maintain balanced self-renewal and differentiation, but
how these functions are precisely regulated is not fully understood. N 6-methyladenosine …
how these functions are precisely regulated is not fully understood. N 6-methyladenosine …
scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
H Yao, CC Gao, D Zhang, J Xu, G Song, X Fan… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) has been demonstrated to regulate RNA metabolism
and various biological processes, including gametogenesis and embryogenesis. However …
and various biological processes, including gametogenesis and embryogenesis. However …
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
Abstract N 6-methyladenosine (m6A) has been identified as the most abundant internal
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …
modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate …
m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency
Summary N 6-methyladenosine (m 6 A) has been recently identified as a conserved
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …