Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities
B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …
endogenous characteristics, however, further bioengineering refinement is required to …
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
DE Murphy, OG de Jong, M Brouwer… - … & molecular medicine, 2019 - nature.com
Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …
Advances in therapeutic applications of extracellular vesicles
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …
Extracellular vesicles as an efficient and versatile system for drug delivery
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …
not been successfully translated into clinical applications. One of the major factors hindering …
Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery
Extracellular vesicles (EVs) hold great promise as potential therapeutic carriers. EVs are
biologically active, intrinsically transporting cargo between cells. Moreover, they can be …
biologically active, intrinsically transporting cargo between cells. Moreover, they can be …
Shedding light on extracellular vesicle biogenesis and bioengineering
F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …
Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine
TN Lamichhane, S Sokic, JS Schardt… - … Engineering Part B …, 2015 - liebertpub.com
Extracellular vesicles (EVs)—comprising a heterogeneous population of cell-derived lipid
vesicles including exosomes, microvesicles, and others—have recently emerged as both …
vesicles including exosomes, microvesicles, and others—have recently emerged as both …
Functional extracellular vesicles for regenerative medicine
The unique biological characteristics and promising clinical potential of extracellular
vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as …
vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as …
Therapeutic applications of extracellular vesicles: clinical promise and open questions
B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …
Extracellular vesicles: potential roles in regenerative medicine
OG De Jong, BWM Van Balkom… - Frontiers in …, 2014 - frontiersin.org
Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …
multivesicular body with the cell membrane, and microvesicles, which are released directly …
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