Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

DE Murphy, OG de Jong, M Brouwer… - … & molecular medicine, 2019 - nature.com
Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …

Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Extracellular vesicles as an efficient and versatile system for drug delivery

XTT Dang, JM Kavishka, DX Zhang, M Pirisinu, MTN Le - Cells, 2020 - mdpi.com
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

D Ingato, JU Lee, SJ Sim, YJ Kwon - Journal of controlled release, 2016 - Elsevier
Extracellular vesicles (EVs) hold great promise as potential therapeutic carriers. EVs are
biologically active, intrinsically transporting cargo between cells. Moreover, they can be …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine

TN Lamichhane, S Sokic, JS Schardt… - … Engineering Part B …, 2015 - liebertpub.com
Extracellular vesicles (EVs)—comprising a heterogeneous population of cell-derived lipid
vesicles including exosomes, microvesicles, and others—have recently emerged as both …

Functional extracellular vesicles for regenerative medicine

HY Kim, S Kwon, W Um, S Shin, CH Kim, JH Park… - Small, 2022 - Wiley Online Library
The unique biological characteristics and promising clinical potential of extracellular
vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as …

Therapeutic applications of extracellular vesicles: clinical promise and open questions

B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …

Extracellular vesicles: potential roles in regenerative medicine

OG De Jong, BWM Van Balkom… - Frontiers in …, 2014 - frontiersin.org
Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …