Abstract Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to
hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF …

The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …

Recent advances in radiotherapy technology now enable us to deliver a booster dose of
radiation to small target fractions in a malignant tumor. To fully exploit this technology in …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental
pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is …

PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is currently
discussed as a potential endogenous marker of tumor hypoxia to select patients for modified …

Hypoxia is a common feature in tumors associated with an increased resistance of tumor
cells to therapies. In addition to O2 diffusion–limited hypoxia, another form of tumor hypoxia …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …