Long noncoding RNAs in cancer: from discovery to therapeutic targets
R Choudhari, MJ Sedano, AL Harrison… - Advances in clinical …, 2020 - Elsevier
Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …
players in biological regulation; however, the mechanisms by which lncRNAs govern …
[HTML][HTML] Challenges and strategies in ascribing functions to long noncoding RNAs
Long noncoding RNAs (lncRNAs) are involved in many physiological and pathological
processes, such as development, aging, immunity, and cancer. Mechanistically, lncRNAs …
processes, such as development, aging, immunity, and cancer. Mechanistically, lncRNAs …
Cooperation and competition by RNA-binding proteins in cancer
Post-transcriptional regulation of gene expression plays a major role in determining the
cellular proteome in health and disease. Post-transcriptional control mechanisms are …
cellular proteome in health and disease. Post-transcriptional control mechanisms are …
[HTML][HTML] Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis
LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of
the major functions of lncRNAs is the regulation of specific gene expression at multiple steps …
the major functions of lncRNAs is the regulation of specific gene expression at multiple steps …
Targetable long non-coding RNAs in cancer treatments
Aberrant expression of many long non-coding RNAs has been observed in various types of
cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging …
cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging …
Therapeutic targeting of long non-coding RNAs in cancer
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
lncRNAfunc: a knowledgebase of lncRNA function in human cancer
The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …
physiological processes and their dysfunction can impact diverse human diseases. To date …
[HTML][HTML] Comprehensive genomic characterization of RNA-binding proteins across human cancers
ZL Wang, B Li, YX Luo, Q Lin, SR Liu, XQ Zhang… - Cell reports, 2018 - cell.com
RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some
are reported to be involved in human tumorigenesis. However, little is known about the …
are reported to be involved in human tumorigenesis. However, little is known about the …
[HTML][HTML] The functional role of long non-coding RNA in human carcinomas
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
From biomarkers to therapeutic targets—the promises and perils of long non-coding RNAs in cancer
Biomarker-driven personalized cancer therapy is a field of growing interest, and several
molecular tests have been developed to detect biomarkers that predict, eg, response of …
molecular tests have been developed to detect biomarkers that predict, eg, response of …