Formerly considered to serve only as structural components, sphingolipids are emerging as
an important group of signaling molecules involved in many cellular events, including cell …

Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural
roles in cellular membranes, some metabolites, including ceramide, sphingosine, and …

The recent discovery of sphingolipid-derived second messengers that regulate fundamental
cell responses such as cell growth and apoptosis has provided insight into the way cells …

Sphingolipids and their metabolites, ceramide, sphingosine and sphingosine-1-phosphate,
are involved in a variety of cellular processes including differentiation, cellular senescence …

Recently, the sphingolipid metabolites ceramide, sphingosine, ceramide 1-P, and
sphingosine 1-P have been implicated as second messengers involved in many different …

Since their discovery over 100 years ago, sphingolipids have caught the eyes and the
imagination of scientists. Modern science has made many new insights on the cell biology …

Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases,
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …

Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora
of functions from the formation of structural domains to polarized cellular trafficking and …

It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

Sphingolipids, universal components of biological membranes of all eukaryotic organisms,
from yeasts to mammals, in addition of playing a structural role, also play an important part of …