Machine learning for drug-target interaction prediction

R Chen, X Liu, S Jin, J Lin, J Liu - Molecules, 2018 - mdpi.com
Identifying drug-target interactions will greatly narrow down the scope of search of candidate
medications, and thus can serve as the vital first step in drug discovery. Considering that in …

Deep learning in drug target interaction prediction: current and future perspectives

K Abbasi, P Razzaghi, A Poso… - Current Medicinal …, 2021 - ingentaconnect.com
Drug-target Interactions (DTIs) prediction plays a central role in drug discovery.
Computational methods in DTIs prediction have gained more attention because carrying out …

Machine learning approaches and databases for prediction of drug–target interaction: a survey paper

M Bagherian, E Sabeti, K Wang… - Briefings in …, 2021 - academic.oup.com
The task of predicting the interactions between drugs and targets plays a key role in the
process of drug discovery. There is a need to develop novel and efficient prediction …

DeepPurpose: a deep learning library for drug–target interaction prediction

K Huang, T Fu, LM Glass, M Zitnik, C Xiao… - Bioinformatics, 2020 - academic.oup.com
Accurate prediction of drug–target interactions (DTI) is crucial for drug discovery. Recently,
deep learning (DL) models for show promising performance for DTI prediction. However …

Network-based methods for prediction of drug-target interactions

Z Wu, W Li, G Liu, Y Tang - Frontiers in pharmacology, 2018 - frontiersin.org
Drug-target interaction (DTI) is the basis of drug discovery. However, it is time-consuming
and costly to determine DTIs experimentally. Over the past decade, various computational …

Comparison study of computational prediction tools for drug-target binding affinities

M Thafar, AB Raies, S Albaradei, M Essack… - Frontiers in …, 2019 - frontiersin.org
The drug development is generally arduous, costly, and success rates are low. Thus, the
identification of drug-target interactions (DTIs) has become a crucial step in early stages of …

Deep learning-based transcriptome data classification for drug-target interaction prediction

L Xie, S He, X Song, X Bo, Z Zhang - BMC genomics, 2018 - Springer
Background The ability to predict the interaction of drugs with target proteins is essential to
research and development of drug. However, the traditional experimental paradigm is costly …

Application of machine learning for drug–target interaction prediction

L Xu, X Ru, R Song - Frontiers in genetics, 2021 - frontiersin.org
Exploring drug–target interactions by biomedical experiments requires a lot of human,
financial, and material resources. To save time and cost to meet the needs of the present …

DASPfind: new efficient method to predict drug–target interactions

W Ba-Alawi, O Soufan, M Essack, P Kalnis… - Journal of …, 2016 - Springer
Background Identification of novel drug–target interactions (DTIs) is important for drug
discovery. Experimental determination of such DTIs is costly and time consuming, hence it …

Padme: A deep learning-based framework for drug-target interaction prediction

Q Feng, E Dueva, A Cherkasov, M Ester - arXiv preprint arXiv:1807.09741, 2018 - arxiv.org
In silico drug-target interaction (DTI) prediction is an important and challenging problem in
biomedical research with a huge potential benefit to the pharmaceutical industry and …