Separating the contributions of SLC26A9 and CFTR to anion secretion in primary human bronchial epithelia

MB Larsen, JJ Choi, X Wang… - … of Physiology-Lung …, 2021 - journals.physiology.org
Aberrant anion secretion across the bronchial epithelium is associated with airway disease,
most notably in cystic fibrosis. Although the cystic fibrosis transmembrane conductance …

SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia

CA Bertrand, R Zhang, JM Pilewski… - Journal of General …, 2009 - rupress.org
Human bronchial epithelial (HBE) cells exhibit constitutive anion secretion that is absent in
cells from cystic fibrosis (CF) patients. The identity of this conductance is unknown, but …

[HTML][HTML] Role of the SLC26A9 chloride channel as disease modifier and potential therapeutic target in cystic fibrosis

A Balázs, MA Mall - Frontiers in pharmacology, 2018 - frontiersin.org
The solute carrier family 26, member 9 (SLC26A9) is an epithelial chloride channel that is
expressed in several organs affected in patients with cystic fibrosis (CF) including the lungs …

The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9

CA Bertrand, S Mitra, SK Mishra… - … of Physiology-Lung …, 2017 - journals.physiology.org
Several members of the SLC26A family of anion transporters associate with CFTR, forming
complexes in which CFTR and SLC26A functions are reciprocally regulated. These …

SLC26A9 in airways and intestine: secretion or absorption?

K Kunzelmann, R Centeio, J Ousingsawat, K Talbi… - Channels, 2023 - Taylor & Francis
ABSTRACT SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion
transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the …

Inhibition of the sodium-dependent HCO3-transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

V Saint-Criq, A Guequén, AR Philp, S Villanueva… - Elife, 2022 - elifesciences.org
Bicarbonate secretion is a fundamental process involved in maintaining acid-base
homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in …

[HTML][HTML] Expression of SLC26A9 in airways and its potential role in asthma

J Ousingsawat, R Centeio, R Schreiber… - International journal of …, 2022 - mdpi.com
SLC26A9 is an epithelial anion transporter with a poorly defined function in airways. It is
assumed to contribute to airway chloride secretion and airway surface hydration. However …

Differential contribution of SLC26A9 to Cl conductance in polarized and non‐polarized epithelial cells

J Ousingsawat, R Schreiber… - Journal of cellular …, 2012 - Wiley Online Library
SLC26 proteins function as anion exchangers and Cl− channels. SLC26A9 has been
proposed to be a constitutively active and CFTR‐regulated anion conductance in human …

[PDF][PDF] The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and …

S Jo, R Centeio, J Park, J Ousingsawat… - The FASEB …, 2022 - mediatum.ub.tum.de
The solute carrier 26 family member A9 (SLC26A9) is an epithelial anion transporter that is
assumed to contribute to airway chloride secretion and surface hydration. Whether …

[HTML][HTML] SLC26A9 as a potential modifier and therapeutic target in cystic fibrosis lung disease

G Gorrieri, F Zara, P Scudieri - Biomolecules, 2022 - mdpi.com
SLC26A9 belongs to the solute carrier family 26 (SLC26), which comprises membrane
proteins involved in ion transport mechanisms. On the basis of different preliminary findings …