Bax is a multidomain, proapoptotic member of the Bcl-2 family that is required for normal
spermatogenesis in mice. Despite its proapoptotic function, previous results found that Bax …

Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the
physiological significance and molecular mechanisms of this programmed cell death are …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

Bcl6 protein has been detected in testicular germ cells, mainly spermatocytes, of normal
mice, but its physiological role is largely unknown. The number of spermatozoa in the cauda …

Restricted germ cell loss through apoptosis is initiated in the fetal gonad around embryonic
day 13.5 (E13. 5) as part of normal germ cell development. The mechanism of this germ cell …

Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl‐
2 family members Bax, Bcl‐2, Bcl‐xs, and Bcl‐xl in male germ cell density‐related apoptosis …

Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

Mature sperm are the product of a precisely regulated developmental sequence in which
germ cell proliferation, differentiation, self‐renewal and apoptosis are carefully controlled …

The BH3‐only proteins of the Bcl‐2 family initiate apoptosis through the activation of Bax‐
like relatives. Loss of individual BH3‐only proteins can lead either to no phenotype, as in …