Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

[HTML][HTML] Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis

H Liu, H Zhang, S Wang, J Cui, W Weng, X Liu… - Composites Part B …, 2023 - Elsevier
Osteoporosis (OP), characterized by decreased bone mass and destruction of bone
microarchitecture, is the most common bone degenerative disease. Conventional treatments …

Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor …

A Liu, D Lin, H Zhao, L Chen, B Cai, K Lin, SGF Shen - Biomaterials, 2021 - Elsevier
Mesenchymal stem cell-derived exosomes (MSC-exos), with its inherent capacity to
modulate cellular behavior, are emerging as a novel cell-free therapy for bone regeneration …

Adipose Mesenchymal Stem Cell Derived Exosomes Promote Keratinocytes and Fibroblasts Embedded in Collagen/Platelet‐Rich Plasma Scaffold and Accelerate …

Y Wang, Y Zhang, T Li, K Shen, KJ Wang… - Advanced …, 2023 - Wiley Online Library
Engineered skin substitutes derived from human skin significantly reduce inflammatory
reactions mediated by foreign/artificial materials and are consequently easier to use for …

Engineered exosome-functionalized extracellular matrix-mimicking hydrogel for promoting bone repair in glucocorticoid-induced osteonecrosis of the femoral head

C Chen, L Fu, Y Luo, W Zeng, X Qi, Y Wei… - … Applied Materials & …, 2023 - ACS Publications
Glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) is a serious bone
disease that often affects young individuals. Bone grafting combined with core …

[PDF][PDF] Exosomes derived from bone marrow mesenchymal stem cells improve osteoporosis through promoting osteoblast proliferation via MAPK pathway.

P Zhao, L Xiao, J Peng, YQ Qian… - European Review for …, 2018 - europeanreview.org
OBJECTIVE: Osteoporosis is the most common bone metabolic disease. Exosome exerts a
crucial role in the development of multiple diseases. The aim of the study was to investigate …

Bone‐targeted exosomes: strategies and applications

J Wang, X Li, S Wang, J Cui, X Ren… - Advanced healthcare …, 2023 - Wiley Online Library
As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

[HTML][HTML] A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

Y Cui, Y Guo, L Kong, J Shi, P Liu, R Li, Y Geng… - Bioactive materials, 2022 - Elsevier
The complex pathogenesis of osteoporosis includes excessive bone resorption, insufficient
bone formation and inadequate vascularization, a combination which is difficult to …

Biotin–avidin system-based delivery enhances the therapeutic performance of MSC-derived exosomes

D Deng, X Li, JJ Zhang, Y Yin, Y Tian, D Gan, R Wu… - ACS …, 2023 - ACS Publications
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents
that promote wound healing and regeneration, but when used alone in vivo, their …

[HTML][HTML] Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of …

X Zhao, L Fu, H Zou, Y He, Y Pan, L Ye… - Journal of …, 2023 - Springer
Background Angiogenesis and tissue repair in chronic non-healing diabetic wounds remain
critical clinical problems. Engineered MSC-derived exosomes have significant potential for …