Nine patients who had an osteosarcoma that had developed as a second malignant
neoplasm in a previously irradiated site were managed at a major center for the treatment of …

~T~~~l~.~ CC) l~ A; a rare malignant Page 1 548 TUMORS Osteosarcoma in 2 Very Young
Children Judith Wilimas, MD, Gene Barrett, MD, Charles Pratt, MD Supported in part by Cancer …

Three cases of postirradiation osteosarcoma which presented in childhood are reported and
the pertinent literature reviewed. The children had been treated in each instance before the …

Osteosarcoma is a rare malignant tumor of bone that produces osteoid. Most tumors arise in
the metaphyses of long bones. At least 80 per cent of patients have subclini-cal metastases …

Osteosarcoma is principally a disease of the pre-teenager and teenage individual. Pain and
swelling of an extremity are the usual initial symptoms. A number of neoplastic and …

This study explores the relationship between histologic variants of bone sarcomas and
previous therapy in patients in whom an unrelated malignant neoplasm had been …

Osteosarcoma is the most common type of bone cancer in children and young adults with a
peak incidence in adolescents. It has a propensity for lung metastases and is a prime …

The objectives of the study were to compare the results of surgical procedures, amputation
and limb-sparing surgery, and to assess the influence of preoperative chemotherapeutic …

Ninety-eight pediatric patients were treated with three separate protocols (Treatment and
investigation of Osteosarcoma [TIOS] I, II, and III) and 47 developed recurrent disease …

PURPOSE AND METHODS Between January 1981 and June 1993, 137 children and
adolescents were each treated at the Institut Gustave Roussy for an initially nonmetastatic …