Although simple arylpiperazines are commonly considered to be moderately selective for 5-
HT1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …

Studies of the serotonin (5-HT) receptors have illustrated several important concepts in G-
protein-mediated signaling. These concepts include G-protein specificity and cellular …

G-protein-coupled receptors or GPCRs have been a major area of study in the past
decades. This is not surprising as this group, comprising a thousand-odd proteins …

hydroxytryptamine (5-HT, also known as serotonin) regulates many physiological processes
through the 5-HT receptor family. Here we report the crystal structure of 5-HT1B subtype …

Serotonin (S-hydroxytryptamine; SHT) is a biogenic amine that functions as both a
neurotransmitter and a hormone in the mammalian central nervous system (CNS) and in the …

The physiological effect of serotonin (5-HT) is mediated in the central and periphery systems
by seven subtypes of receptors. All but one are members of the G protein coupled receptor …

Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is
now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early …

Of the 14 known types of serotonin receptors one of the most extensively studied is the 5‐
HT2A (5‐hydroxytryptamine) receptor. In the brain, this receptor plays a key role in …

Blockade of the serotonin 5-HT 2A G protein-coupled receptor (5-HT 2A R) is a fundamental
pharmacological characteristic of numerous antipsychotic medications, which are FDA …