A correlation between high plasma serotonin levels and total pulmonary resistance was
reported in more than 80% of pulmonary hypertensive patients. When submitted to chronic …

Four major families of serotonin (5-hydroxytryptamine; 5-HT) receptors have been identified:
5-HT 1, 5-HT 2, 5-HT 3 and 5-HT 4. At this time, there is a general consensus that the 5-HT 1 …

We describe the cloning and characterization of a human 5‐HT6 serotonin receptor. The
open reading frame is interrupted by two introns in positions corresponding to the third …

Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

Site-directed mutagenesis and molecular modeling were used to investigate the molecular
interactions involved in ligand binding to, and activation of, the rat 5-hydroxytryptamine2A (5 …

We report the cloning and the deduced amino acid sequence of cDNAs encoding both the
human serotonin 5-HT2 and 5-HT1C receptors. The human 5-HT2 and 5-HT1C receptors …

Discovering the molecular and atomic mechanism (s) by which G-protein-coupled receptors
(GPCRs) are activated by agonists remains an elusive goal. Recently, studies examining …

The functional significance of the conserved amino acids within transmembrane regions II
and VII of the human 5-hydroxytryptamine (5-HT) 1A receptor was analyzed by …

Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter, that
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …

The hypothesis that multiple serotonin (5‐hydroxytryptamine; 5‐HT) receptors exist was first
developed in the 1950s. However, unequivocal proof of 5‐HT receptor multiplicity required …