Chronic alcohol abuse alters the molecular structure and function of brain cells. Recent work
suggests adaptations made by glial cells, such as astrocytes and microglia, regulate …

Alcoholism remains a prevalent health concern throughout the world. Previous studies have
identified transcriptomic patterns in the brain associated with alcohol dependence in both …

Microglia are fundamentally important immune cells within the central nervous system (CNS)
that respond to environmental challenges to maintain normal physiological processes …

Astrocytes play critical roles in central nervous system (CNS) homeostasis and are
implicated in the pathogenesis of neurological and psychiatric conditions, including drug …

Alcohol abuse induces changes in microglia morphology and immune function, but whether
microglia initiate or simply amplify the harmful effects of alcohol exposure is still a matter of …

Despite recent extensive genomic and genetic studies on behavioral responses to ethanol,
relatively few new therapeutic targets for the treatment of alcohol use disorder have been …

Repeated ethanol exposure and withdrawal in mice increases voluntary drinking and
represents an animal model of physical dependence. We examined time-and brain region …

Background Microglia, the primary immune cells of the brain, are implicated in alcohol use
disorder. However, it is not known if microglial activation contributes to the transition from …

Alcohol use disorder (AUD) is one of the most common preventable mental health disorders
and can result in pathology within the CNS, including the cerebellum. Cerebellar alcohol …

Long lasting abusive consumption, dependence, and withdrawal are characteristic features
of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are …