Histaminergic H3 receptors modulate the release of neurotransmitters within the CNS and
periphery. Ligands for these receptors have potential clinical utility in a variety of disease …

Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when
dinner is served or orchestrating the elements of inflammation after a mosquito bite …

The pharmacology of histamine H3 receptors suggests the presence of distinct receptor
isoforms or subtypes. We herein describe multiple, functionally distinct, alternatively spliced …

Constitutive activation of G-protein-coupled receptors is a well recognized phenomenon,
and G-protein-coupled receptor antagonists have been found to possess inverse agonist …

We compared radioligand binding and functional data for histamine H3 receptor ligands
across different tissues or species to evaluate the basis for pharmacological evidence of …

Presynaptic histamine H3 receptors (H3R) regulate neurotransmitter release in the central
nervous system, suggesting an important role for H3 ligands in human diseases such as …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Histamine is a multifunctional hormone that regulates smooth muscle contraction in the
airways, acid secretion in the gut, and neurotransmitter release in the central nervous …

Histamine regulates neurotransmitter release in the central and peripheral nervous systems
through H3 presynaptic receptors. The existence of the histamine H3 receptor was …

The recently identified histamine H 4 receptor has revealed a potential new complexity for
the role of histamine in the immune system. To begin to understand the role of this receptor …