Objective While the molecular events controlling insulin secretion from β-cells have been
documented in detail, the exact mechanisms governing glucagon release by α-cells are …

Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by
high glucose levels; impaired suppression of glucagon secretion is a hallmark of both type 1 …

The secretion of glucagon by pancreatic alpha cells is regulated by a number of external
and intrinsic factors. While the electrophysiological processes linking a lowering of glucose …

Aims/hypothesis Type 2 diabetes is caused by relative deficiency of insulin secretion and is
associated with dysregulation of glucagon secretion during the late stage of diabetes …

Glucokinase (GK) catalyzes the phosphorylation of glucose in β-cells and hepatocytes, and
mutations in the GK gene have been implicated in a form of human diabetes. To investigate …

Insulin secretion by the pancreatic β-cells is elicited in response to elevated extracellular
glucose concentration. In addition to triggering insulin secretion, glucose-induced signal …

Glucagon plays a critical counter-regulatory role to insulin to maintain optimal glucose
homeostasis. Glucagon secretion from pancreatic α-cells is regulated by glycemia, neural …

Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the
hypoglycemic action of insulin and strongly contributes to the correction of acute …

The secretion of insulin is controlled by the rate of glucose metabolism in the pancreatic p
cells. As phosphorylation by glucokinase (GLK) appears to be the rate-limiting step for …

Glucokinase (GK) plays a key role in maintaining glucose homeostasis by promoting insulin
secretion from pancreatic beta cells and increasing hepatic glucose uptake. Here we …