Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …

Lung disease is a leading cause of morbidity and mortality worldwide. Innate immune
responses in the lung play a central role in the pathogenesis of lung disease and the …

In normal airways, hyaluronan (HA) matrices are primarily located within the airway
submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following …

Hyaluronan (HA) is a polymer of molecular mass from 2 105 to 10 106 comprising repeating
disaccharide units of glucuronic acid and N-acetyl-D-glucosamine. HA is abundant, present …

Asthma is frequently caused and/or exacerbated by sensitization to allergens, which are
ubiquitous in many indoor and outdoor environments. Severe asthma is characterized by …

Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by
hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti …

Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease.
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …

An important hallmark of tissue remodeling is the dynamic turnover of extracellular matrix
(ECM). ECM performs a variety of functions in tissue repair including scaffold formation …

Hyaluronan, a ubiquitous naturally occurring glycosaminoglycan, is a major component of
the extracellular matrix, where it participates in biological processes that include water …

A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …