Two-arm branched mPEG (monomethoxy-polyethylene glycol) with different molecular
weights (Mn= 4000, 6000, 9400) was synthesized and used as carrier for immobilization of …

In order to provide a new macromolecular prodrug of cisplatin (CDDP, antitumor platinum
complex) having high water-solubility, reduced side-effects and excellent antitumor activity …

Cisplatin was incorporated into polymeric carriers through the coordination of Pt with the
carboxylic groups of methoxy‐poly (ethylene glycol)(mPEG)‐block‐poly [(2‐carboxy …

It is much importance to develop novel multifunctional delivery systems for the combination
therapy of drug and gene. In this work, a novel conjugate, polyethylene glycol …

A biodegradable and amphiphilic copolymer, MPEG-bP (LA-co-MCC), which contains
pendant carboxyl groups, was chosen as a drug carrier for the active anticancer part (DACH …

Abstract cis-Dichloro (cyclohexane-trans-l-1, 2-diamine) platinum (II): Dach-Pt-(chlorato) is a
platinum complex which is expected to exhibit higher antitumor activity than cisplatin and …

The in vivo antitumor activity and toxicity of a newly synthesized polymeric prodrug of
cisplatin was investigated and also compared with plain cisplatin. The prodrug included a …

A new amphiphilic poly (organophosphazene) was synthesized by stepwise nucleophilic
substitutions with a hydrophilic methoxy poly (ethylene glycol) with an average molecular …

The antitumor platinum moiety,(dach) Pt 2+(dach= trans (±)-1, 2-diaminocyclohexane), was
introduced to a poly (organophosphazene) using dicarboxylate spacers, glutamate or …

To provide a macromolecular prodrug with recognition ability for hepatoma cells, we
synthesized new conjugates of cisplatin (CDDP) and poly (ethylene glycol)(PEG) with …