Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators

J Roa, M Tena-Sempere - Molecular and cellular endocrinology, 2014 - Elsevier
It is well established that pubertal activation of the reproductive axis and maintenance of
fertility are critically dependent on the magnitude of body energy reserves and the metabolic …

Interaction between energy homeostasis and reproduction: central effects of leptin and ghrelin on the reproductive axis

M Tena-Sempere - Hormone and Metabolic Research, 2013 - thieme-connect.com
Reproductive maturation and function are sensitive to the metabolic state of the organism
and the magnitude of body fuel reserves; hence, conditions ranging from energy …

Connecting metabolism and gonadal function: novel central neuropeptide pathways involved in the metabolic control of puberty and fertility

M Manfredi-Lozano, J Roa, M Tena-Sempere - Frontiers in …, 2018 - Elsevier
Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …

Metabolic control of puberty onset: new players, new mechanisms

J Roa, D García-Galiano, JM Castellano… - Molecular and cellular …, 2010 - Elsevier
Puberty, as the end-point of a complex series of maturational events affecting the
components of the hypothalamic-pituitary-gonadal (HPG) axis, is gated by the state of body …

Metabolic influences on neuroendocrine regulation of reproduction

VM Navarro, UB Kaiser - Current opinion in endocrinology …, 2013 - journals.lww.com
Metabolic influences on neuroendocrine regulation of reprodu... : Current Opinion in
Endocrinology, Diabetes and Obesity Metabolic influences on neuroendocrine regulation of …

Roles of leptin in reproduction, pregnancy and polycystic ovary syndrome: consensus knowledge and recent developments

MJ Vázquez, A Romero-Ruiz, M Tena-Sempere - Metabolism, 2015 - Elsevier
As an essential function for perpetuation of species, reproduction, including puberty onset, is
sensitive to the size of body energy stores and the metabolic state of the organism …

Neuroendocrine disruption of pubertal timing and interactions between homeostasis of reproduction and energy balance

JP Bourguignon, G Rasier, MC Lebrethon… - Molecular and Cellular …, 2010 - Elsevier
The involvement of environmental factors such as endocrine disrupting chemicals (EDCs) in
the timing of onset of puberty is suggested by recent changes in age at onset of puberty and …

Integrative control of energy balance and reproduction in females

RM Garcia-Garcia - International Scholarly Research Notices, 2012 - Wiley Online Library
There is a strong association between nutrition and reproduction. Chronic dietary energy
deficits as well as energy surpluses can impair reproductive capacity. Metabolic status …

Role of the adipocyte-derived hormone leptin in reproductive control

D Garcia-Galiano, SJ Allen, CF Elias - Hormone molecular biology …, 2014 - degruyter.com
Achievement of sexual maturation and maintenance of fertility in adulthood are functions that
are sensitive to the metabolic status of the organism, particularly the magnitude of fat …

Roles of ghrelin and leptin in the control of reproductive function

M Tena-Sempere - Neuroendocrinology, 2007 - karger.com
Reproductive function in mammals, defined as the capacity to generate viable male and
female gametes, and to support pregnancy and lactation selectively in the female, is …