Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid
metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) …

Ozone (O3) is a criteria air pollutant known to increase the morbidity and mortality of
cardiopulmonary diseases. This occurs through a pulmonary inflammatory response …

Inflammation is an essential mechanism of various diseases. The development and
resolution of inflammation are complex immune-modulation processes which induce the …

Macrophages and inflammatory mediators have been implicated in ozone toxicity. In these
studies, we used splenectomized (SPX) mice to assess the contribution of splenic …

Patients with COPD are associated with poor pulmonary anti-bacterial innate defenses,
which increase the risk for frequent acute exacerbations caused by bacterial infection …

Exposure to air pollution and other environmental inhalation hazards, such as occupational
exposures to dusts and fumes, aeroallergens, and tobacco smoke, is a significant cause of …

Resolution of acute lung inflammation and injury is an active process; it is not merely the
absence of proinflammatory signals. Restoration of homeostasis is coordinated by specific …

Damage associated molecular patterns (DAMPs) are molecules released from dead/dying
cells following toxicant and/or environmental exposures that activate the immune response …

Ozone is a common environmental toxicant to which individuals are exposed to on a daily
basis. While biochemical end points such as increased mortality, decrements in pulmonary …

Exposure to ozone causes decrements in pulmonary function, a response associated with
alterations in lung lipids. Pulmonary lipid homeostasis is dependent on the activity of …