Autophagy is a lysosomal-mediated degradation process that controls the turnover of
organelles and longlived proteins. Outside of its role in maintaining cellular homeostasis …

A deeper understanding of the role of autophagy, literally 'self-eating', in normal and cancer
cell biology has emerged over the last few years. Autophagy serves as a vehicle for cells to …

The common clear cell subtype of renal cell carcinoma is associated with hereditary or
acquired loss of function of the von Hippel-Lindau tumor suppressor, a key component in …

Autophagy is an evolutionary conserved, lysosome-involved cellular process that facilitates
the recycling of damaged macromolecules, cellular structures, and organelles, thereby …

Inhibition of autophagy has been widely explored as a potential therapeutic intervention for
cancer. Different factors such as tumor origin, tumor stage and genetic background can …

Four different functional forms of autophagy have been observed to occur in tumor cells in
response to chemotherapeutic drugs and radiation. Currently the different forms of …

Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to
relieve acute and chronic inflammatory diseases. In this article, we present a review about …

Two primary forms of autophagy have been identified in the field of cancer therapy based on
their apparent functions in the tumor cell; these are the cytoprotective form that could, in …

Induction of cell death and inhibition of cell growth are the main targets of cancer therapy.
Here we evaluated the role of autophagy on chemoresistance of human hepatocarcinoma …

Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …