Prevalence and health consequences of obesity differ between men and women. Yet, most
preclinical studies investigating the etiology of obesity have, to date, been conducted in …

The purpose of this study was to compare weight gain and food intake during high-fat
feeding in outbred CD-1 male mice while considering several different experimental …

We have previously reported suggestive evidence for a locus on Chromosome (Chr) 7 that
affects adiposity in F 2 mice from a CAST/Ei× C57BL/6J intercross fed a high-fat diet. Here …

Objective: Increased dietary fat intake is a precipitating factor for the development of obesity
and associated metabolic disturbances. Physically active individuals generally have a …

Exposure to high vs. low glycemic index (GI) diets increases fat mass and insulin resistance
in obesity-prone C57BL/6J mice. However, the longer-term effects and potentially involved …

The breadth of genetic and phenotypic variation among inbred strains is often
underappreciated because assessments include only a limited number of strains. Evaluation …

Genetic and environmental factors play a role in the development of obesity, and diet is one
of the main environmental factors that contributes to this disease. Human studies have …

Although a number of obesity animal models have been reported, each model possesses
different characteristics of obesity, suggesting care should be taken in choosing an animal …

Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a
predisposition to develop severe obesity if placed on a high-fat diet. In the present study we …

The global obesity epidemic has heightened the need for an improved understanding of
how body weight is controlled, and research using mouse models is critical to this effort. In …