Rationale Few effective treatments exist for cocaine use disorders due to gaps in knowledge
about its complex etiology. Genetically defined animal models provide a useful tool for …

Cocaine use and overdose deaths attributed to cocaine have increased significantly in the
United States in the last 10 years. Despite the prevalence of cocaine use disorder (CUD) …

Cocaine use disorders (CUD) are devastating for affected individuals and impose a
significant societal burden, but there are currently no FDA-approved therapies. The …

It is thought that rewarding experiences with drugs create strong contextual associations and
encourage repeated intake. In turn, repeated exposures to drugs of abuse make lasting …

Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans.
Acute locomotor activation in response to psychostimulants is commonly used as an animal …

Large individual differences exist among mice in their behavioral responses to drugs of
abuse, and many of these differences have a substantial genetic basis. The creation of new …

Application of animal models of psychostimulant abuse for experimentation in mice is
becoming increasingly important for studying the contribution of genetic differences, as well …

Rationale Individual differences in the propensity to acquire drug self-administration may
have a substantial genetic basis. Objectives To study the genetic contribution to cocaine self …

Sensitization to the psychostimulant effects of cocaine has received widespread attention
because concomitant changes occur in neurochemical pathways that are part of the brain …

Background The expanding set of genomics tools available for inbred mouse strains has
renewed interest in phenotyping larger sets of strains. The present study aims to explore …