Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the
development and maintenance of addiction. Rodent studies suggest that this sensitivity is …

Cocaine self‐administration is a complexly determined trait, with a substantial proportion of
individual differences being determined by genetic variation. However, the relevant genetic …

Forward genetic mapping of F2 crosses between closely related substrains of inbred rodents-
referred to as a reduced complexity cross (RCC)-is a relatively new strategy for accelerating …

Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are
subject to individual variability, and genetic variation accounts for at least a portion of those …

Rationale Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but
this relationship is not always observed in human studies. Moreover, studies examining the …

Rationale Combining strains to generate mutant mice may obscure conclusions regarding
the targeted gene. Specifically, cocaine may have reduced reinforcing effects in 129 …

To elucidate genes associated with cocaine's locomotor stimulant effects, we used
recombinant inbred-quantitative trait loci (RI-QTL) analyses to identify chromosomal loci …

Inbred strains of mice are valuable tools for determining the impact of genes and the
environment on behavior. However, use of mice in intravenous (iv) cocaine self …

The current study compares the acute and long-term effects of GBR 12935 and cocaine on
locomotor activity and stereotypy in two genetically distinct strains of mice. Although cocaine …

There is great interest in outlining biological factors and behavioral characteristics that either
predispose or predict vulnerability to substance use disorders. Response to an inescapable …