Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …

1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

A2A adenosine receptors (A2ARs) are expressed with the greatest abundance in the
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …

Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …

There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …

There is growing evidence that adenosine is a potent inhibitor of neuronal activity in the
central (CNS) and peripheral nervous systems. Four major subtypes of adenosine receptors …

To clarify differences in the operating mechanisms of adenosine receptor subtypes (A1 and
A2), striatal extracellular dopamine levels under various conditions were determined by in …