Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease

MI Martinez-Mir, A Probst, JM Palacios - Neuroscience, 1991 - Elsevier
Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections
of the human brain using the A2-selective agonist ligand [3 H](2-p-(2-car☐ yethyl) …

The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 …

JF Chen, R Moratalla, F Impagnatiello… - Proceedings of the …, 2001 - National Acad Sciences
The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain …

HY Shen, JE Coelho, N Ohtsuka… - Journal of …, 2008 - Soc Neuroscience
The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

Evidence for functionally important adenosine A2a receptors in the rat hippocampus

RA Cunha, B Johansson, I van der Ploeg, AM Sebastia… - Brain research, 1994 - Elsevier
Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

Pharmacology of adenosine A2A receptors

E Ongini, BB Fredholm - Trends in pharmacological sciences, 1996 - cell.com
Adenosine A 2A receptors, which have been cloned from several mammalian species, are
activated by physiological concentrations of adenosine to stimulate the formation of cAMP …

Adenosine A1 receptor-mediated depression of corticostriatal and thalamostriatal glutamatergic synaptic potentials in vitro

I Flagmeyer, HL Haas, DR Stevens - Brain research, 1997 - Elsevier
Electrophysiological recordings in rat brain slices have been used to study the actions of
adenosine on striatal neurons and striatal excitatory amino acid neurotransmission …

Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission

A Tozzi, A Tscherter, V Belcastro, M Tantucci… - …, 2007 - Elsevier
Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

Activation of Adensine A1 and A2A Receptors Modulates Dopamine D2 Receptor‐Induced Responses in Stably Transfected Human Neuroblastoma Cells

H Salim, S Ferré, A Dalal, RA Peterfreund… - Journal of …, 2000 - Wiley Online Library
Adenosine can influence dopaminergic neuro‐transmission in the basal ganglia via
postsynaptic inter‐action between adenosine A2A and dopamine D2 receptors. We have …

Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system

DL Rosin, A Robeva, RL Woodard… - Journal of …, 1998 - Wiley Online Library
The A2A adenosine receptor (A2A‐AR) transcript and radioligand binding sites have a
distinct distribution in rat brain, restricted primarily to the striatum, nucleus accumbens and …

Reciprocal interactions between adenosine A2A and dopamine D2 receptors in Chinese hamster ovary cells co-transfected with the two receptors

B Kull, S Ferré, G Arslan, P Svenningsson… - Biochemical …, 1999 - Elsevier
Human adenosine A2A and rat dopamine D2 receptors (A2A and D2 receptors) were co-
transfected in Chinese hamster ovary (CHO) cells to study the interactions between two …