From behavioural and biochemical experiments, we have found evidence for the existence
of a specific adenosine A2a receptor/dopamine D2 receptor interaction in the brain …

Human adenosine A2A and rat dopamine D2 receptors (A2A and D2 receptors) were co-
transfected in Chinese hamster ovary (CHO) cells to study the interactions between two …

Adenosine is known to modulate the function of neostriatal neurons. Adenosine acting on
A2A receptors increases the phosphorylation of dopamine-and cAMP-regulated …

Adenosine exerts its physiological actions by binding to G-protein coupled receptors, four of
which have been identified and cloned to date (A1, A2a, A2b and A3). Here we report the …

Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for
the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists …

Adenosine A2A receptor antagonists have been proposed as an effective therapy in the
treatment of Parkinson's disease. To explore the possibility that dopamine denervation may …

It has been shown that striatal adenosine A2A receptors can antagonistically interact with
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …

Brain adenosine A2A receptors have recently attracted considerable attention because of
their interaction with the dopaminergic system and as potential targets for Parkinson's …

The antagonistic interactions between adenosine A 1 and dopamine D 1 receptors were
studied in a mouse Ltk− cell line stably cotransfected with human adenosine A 1 receptor …

In rats with unilateral 6‐hydroxydopamine lesions of the dopaminergic nigrostriatal pathway,
administration of the A2a adenosine antagonist SCH 58261 alone did not induce any motor …