Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia,
activated by the neuromodulator adenosine, which interact with dopamine D2 receptors …

The adenosine A3 receptor is expressed in brain, but the consequences of activation of this
receptor on electrophysiological activity are unknown. We have characterized the actions of …

Adenosine A 2A receptor antagonism is a new therapeutic strategy in the symptomatic
treatment of Parkinson's disease (PD). This review addresses how adenosine A 2A …

Adenosine A2A receptors have a unique cellular and regional distribution in the basal
ganglia, being particularly concentrated in areas richly innervated by dopamine such as the …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

A novel receptor cDNA was isolated from a human hippocampal cDNA library. The encoded
polypeptide contains structural features consistent with its classification as a G protein …

There is now good reason to believe that blockade of the adenosine A 2A receptor could be
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

Evaluation of adenosine A2 receptor function in the mammalian CNS has been impeded by
the lack ofhighly selective A2 receptor agonists. The present investigations describe the …

Adenosine and dopamine are two important modulators of glutamatergic neurotransmission
in the striatum. However, conflicting reports exist about the role of adenosine and adenosine …