Targeted drug delivery via folate receptors
Targeted delivery via selective cellular markers can potentially increase the efficacy and
reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl …
reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl …
Clinical translation of folate receptor-targeted therapeutics
L Teng, J Xie, L Teng, RJ Lee - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Folate receptor− α (FR− α) has been established as a membrane marker for
ovarian cancer. In addition, it is frequently overexpressed in other major types of epithelial …
ovarian cancer. In addition, it is frequently overexpressed in other major types of epithelial …
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
AR Hilgenbrink, PS Low - Journal of pharmaceutical sciences, 2005 - Elsevier
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …
The folate receptor as a rational therapeutic target for personalized cancer treatment
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
Folate-targeted chemotherapy
The folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …
drug conjugates with very high affinity and shuttles these bound molecules inside cells via …
Folate-mediated targeting of therapeutic and imaging agents to cancers
The vitamin folic acid (FA) enters cells either through a carrier protein, termed the reduced
folate carrier, or via receptor-mediated endocytosis facilitated by the folate receptor (FR) …
folate carrier, or via receptor-mediated endocytosis facilitated by the folate receptor (FR) …
Targeting therapeutic and imaging agents to folate receptor positive tumors
JA Reddy, VM Allagadda… - Current pharmaceutical …, 2005 - ingentaconnect.com
The membrane-bound folate receptor (FR) is overexpressed on a wide range of human
cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain …
cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain …
Exploitation of the folate receptor in the management of cancer and inflammatory disease
CP Leamon, AL Jackman - Vitamins & Hormones, 2008 - Elsevier
Over the last 25+ years, the folate receptor (FR) has emerged as an attractive tumor
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …
biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence …
[HTML][HTML] Active targeted nanoformulations via folate receptors: State of the art and future perspectives
C Martín-Sabroso, AI Torres-Suárez… - Pharmaceutics, 2021 - mdpi.com
In normal tissues, the expression of folate receptors is low and limited to cells that are
important for embryonic development or for folate reabsorption. However, in several …
important for embryonic development or for folate reabsorption. However, in several …
The folate receptor: what does it promise in tissue-targeted therapeutics?
MDA Salazar, M Ratnam - Cancer and Metastasis Reviews, 2007 - Springer
For over a decade the folate receptor has been intensively investigated as a means for
tumor-specific delivery of a broad range of experimental therapies including several …
tumor-specific delivery of a broad range of experimental therapies including several …