We have shown that Wnt5A increases the motility of melanoma cells. To explore cellular
pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) …

Gene expression profiling identified human melanoma cells demonstrating increased cell
motility and invasiveness. The gene WNT5A best determined in vitro invasive behavior …

Expression of Snail has been shown to mediate epithelial–mesenchymal transition (EMT) of
epithelial cells and carcinomas, characterized by morphological alterations with …

Wnt5a activates the Wnt/β-catenin-independent pathway and its overexpression is
associated with tumor aggressiveness enhancing invasive activity. For this action, Wnt5a …

The influential role of Wnt5a in tumor progression underscores the requirement for
developing molecules that can target Wnt5a-mediated cellular responses. In the aggressive …

Wnt5a is one of the so-called non-canonical Wnt ligands which do not act through β-catenin.
In normal development, Wnt5a is secreted and directs the migration of target cells along …

In contrast to the transforming members of the Wnt family, shown to be upregulated in many
cancers, the role of Wnt 5a is still controversial. While it has been attributed a tumour …

Oncogenic targets acting in both tumor cells and tumor stromal cells may offer special
therapeutic appeal. Interrogation of the Oncomine database revealed that 52 of 53 human …

Wnt-5a is a non-transforming Wnt protein that is implicated in cell polarity, adhesion, and
motility. We have previously shown that low expression of Wnt-5a is a predictor of shorter …

Elevated expression of the orphan nuclear receptor estrogen-related receptor α (ERRα) has
been associated with a negative outcome in several cancers, although the mechanism (s) by …