Cytokines, Signaling Pathways, and Effector Molecules Required for the Control of Leishmania (Viannia) braziliensis in Mice

FJS Rocha, U Schleicher, J Mattner, G Alber… - Infection and …, 2007 - Am Soc Microbiol
Cutaneous leishmaniasis is caused by protozoan parasites of the genus Leishmania. The
mechanisms of pathogen control have been established primarily in the mouse model of …

Murine model of chronic L. (Viannia) panamensis infection: Role of IL‐13 in disease

TM Castilho, K Goldsmith‐Pestana… - European journal of …, 2010 - Wiley Online Library
Leishmania (Viannia) organisms are the most prevalent etiologic agents of human
cutaneous leishmaniasis in the Americas. Nevertheless, our knowledge of the …

BALB/c Mice Infected with Antimony Treatment Refractory Isolate of Leishmania braziliensis Present Severe Lesions due to IL-4 Production

DL Costa, V Carregaro, DS Lima-Júnior… - PLoS neglected …, 2011 - journals.plos.org
Background Leishmania braziliensis is the main causative agent of cutaneous leishmaniasis
in Brazil. Protection against infection is related to development of Th1 responses, but the …

Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection with Leishmania amazonensis

J Ji, J Sun, L Soong - Infection and immunity, 2003 - Am Soc Microbiol
Infection of mice with Leishmania major results in disease progression or resolution, largely
depending on the genetic backgrounds of the mouse strains. Infection with Leishmania …

Control of New World cutaneous leishmaniasis is IL‐12 independent but STAT4 dependent

LU Buxbaum, JE Uzonna… - European journal of …, 2002 - Wiley Online Library
Abstract Leishmania mexicana, a New World protozoan parasite, induces small, chronic, but
non‐progressive lesions in C57BL/6 (B6) mice. In this study we investigated the role of IL …

A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.

YA Skeiky, JA Guderian, DR Benson… - The Journal of …, 1995 - rupress.org
Leishmania braziliensis causes cutaneous and mucosal leishmaniasis in humans. Most
patients with cutaneous leishmaniasis heal spontaneously and may therefore have …

Immunopathogenesis of infection with the visceralizing Leishmania species

ME Wilson, SMB Jeronimo, RD Pearson - Microbial pathogenesis, 2005 - Elsevier
Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving
infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap …

IL-10 and TGF-β control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice

CF Anderson, R Lira, S Kamhawi, Y Belkaid… - The journal of …, 2008 - journals.aai.org
Leishmania tropica is the causative agent of Old World anthroponotic cutaneous
leishmaniasis, which is characterized by lesions that take an extended period of time to heal …

Subversion and Utilization of Host Innate Defense by Leishmania amazonensis

L Soong - Frontiers in immunology, 2012 - frontiersin.org
Infection with Leishmania amazonensis and other members of the Leishmania mexicana
complex can lead to diverse clinical manifestations, some of which are relatively difficult to …

Resolution of an infection with Leishmania braziliensis confers complete protection to a subsequent challenge with Leishmania major in BALB/c mice

HC Lima, GK DeKrey, RG Titus - Memórias do Instituto Oswaldo Cruz, 1999 - SciELO Brasil
Both Leishmania major and L. braziliensis induce cutaneous leishmaniasis in BALB/c mice.
Whereas BALB/c mice die of infection with L. major, they cure an infection with L …