Molecular mechanisms of remodeling in human atrial fibrillation

BJJM Brundel, RH Henning… - Cardiovascular …, 2002 - academic.oup.com
An important acknowledgement of the last several years is that atrial fibrillation (AF) modifies
the electrical properties of the atrium in a way that promotes its occurrence and …

Molecular basis of electrical remodeling in atrial fibrillation

DR Van Wagoner, JM Nerbonne - Journal of molecular and cellular …, 2000 - Elsevier
DR Van Wagoner and JM Nerbonne. Molecular Basis of Electrical Remodeling in Atrial
Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1101–1117. Atrial …

Electrical remodeling in atrial fibrillation

D Dobrev - Herz, 2006 - search.proquest.com
Electrical remodeling refers to any change in electrical function that promotes atrial
fibrillation (AF). A key advance in understanding the mechanisms of AF has been the …

Dynamic remodeling of intracellular Ca2+ signaling during atrial fibrillation

M Greiser, U Schotten - Journal of molecular and cellular cardiology, 2013 - Elsevier
During atrial fibrillation (AF) intracellular Ca2+ signaling in atrial myocytes changes
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics

D Dobrev, S Nattel - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …

Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation

BJJM Brundel, HH Kampinga… - Cardiovascular …, 2004 - academic.oup.com
Objective: Atrial fibrillation (AF) is a progressive disease. Previously, clinical and animal
experimental studies in AF revealed a variety of myocyte remodeling processes including L …

Structural remodelling during chronic atrial fibrillation: act of programmed cell survival

VLJL Thijssen, J Ausma, M Borgers - Cardiovascular research, 2001 - academic.oup.com
Atrial fibrillation is the most common cardiac arrhythmia with an overall prevalence of almost
1%. Increasing prevalence and associated risks such as stroke and mortality have increased …

Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation

S Nattel - Cardiovascular research, 1999 - academic.oup.com
One of the most exciting developments in our understanding of atrial fibrillation (AF) over the
last several years has been the recognition that AF itself modifies atrial electrical properties …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …