The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors
(ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and …

Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an
extracellular signalling molecule via a rich array of receptors, which have been cloned and …

The coupling of the four defined types of adenosine receptors to G proteins and the
consequent activation of effector pathways is briefly summarized. It is pointed out that the G …

It is a component or precursor to a component of RNA and DNA, and in its native form, of in
various phosphorylated states, acts as a neurotransmitter at the P1 and P2 purine receptors …

Membrane receptors that are activated by the purine nucleoside adenosine (adenosine
receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce …

Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …

It is now well accepted that G protein-coupled receptors (GPCRs) can be directly associated,
as either homo-or hetero-oligomers, to alter their functions. G protein-coupled purinergic …

The occurrence of a physiologically relevant release of adenine nucleotides that results in
the activation of cell surface receptors was formally postulated several decades ago',?. More …

Adenosine and its endogenous precursor ATP are main components of the purinergic
system that modulates cellular and tissue functions via specific adenosine and ATP …

Adenosine and ATP modulate cellular and tissue functions via specific P1 and P2 receptors,
respectively. Although, in general, adenosine inhibits excitability and ATP functions as an …