CcpA is the global mediator of carbon catabolite repression (CCR) in gram-positive bacteria,
and growing evidence from several pathogens, including the group A streptococcus (GAS) …

Although central to pathogenesis, the molecular mechanisms used by microbes to regulate
virulence factor production in specific environments during host–pathogen interaction are …

To achieve maximum fitness, pathogens must balance growth with tissue damage,
coordinating metabolism and virulence factor expression. In the gram-positive bacterium …

The Streptococcus mutans Cid/Lrg system represents an ideal model for studying this
organism's ability to withstand various stressors encountered in the oral cavity. The lrg and …

CcpA globally regulates transcription in response to carbohydrate availability in many gram-
positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan …

Carbon catabolite repression (CCR) allows bacteria to alter metabolism in response to the
availability of specific sugar sources, and increasing evidence suggests that CCR is …

Production of H2O2 follows a growth phase-dependent pattern that mimics that of many
virulence factors of Streptococcus pyogenes. To gain greater insight into mechanisms …

Group A streptococcus (GAS) is a gram-positive human bacterial pathogen that causes
diseases ranging from relatively mild epithelial cell surface infections to life-threatening …

S treptococcus suis (S. suis) is a neglected zoonotic streptococcus causing fatal diseases in
humans and in pigs. The transcriptional regulator CcpA (catabolite control protein A) is …

Molecular mechanisms mediating group A Streptococcus (GAS)-host interactions remain
poorly understood but are crucial for diagnostic, therapeutic, and vaccine development. An …