As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …

The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

Polymorphonuclear neutrophils (PMNs) form the first line of defense against invading
microorganisms. We have shown previously that ATP release and autocrine purinergic …

Metabolic rewiring underlies the effector functions of macrophages,–, but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …

Complex interplay between T helper (Th) cells and macrophages contributes to the
formation and progression of atherosclerotic plaques. While Th1 cytokines promote …

Innate immune responses are intricately linked with intracellular metabolism of myeloid
cells. Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis …

Macrophages play a major role in the immune system, both as antimicrobial effector cells
and as immunoregulatory cells, which induce, suppress or modulate adaptive immune …

Metabolic adaptations can directly influence the scope and scale of macrophage activation
and polarization. Here we explore the impact of type I interferon (IFNβ) on macrophage …

During the inflammatory response, macrophage phenotypes can be broadly classified as
pro-inflammatory/classically activated “M1”, or pro-resolving/alternatively “M2” …

Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers
and differential production of soluble mediators. These immune cells play key roles in …