Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

BACKGROUND Metabolism can be broadly divided into anabolic, energy-consuming,
biosynthetic processes and energy-generating catabolic processes. Different biological …

During wound injury, efferocytosis fills the macrophage with a metabolite load nearly equal
to the phagocyte itself. A timely question pertains to how metabolic phagocytic signaling …

Macrophages are not only essential components of innate immunity that contribute to host
defense against infections, but also tumor growth and the maintenance of tissue …

Polarization of macrophages into pro-inflammatory or anti-inflammatory states has distinct
metabolic requirements, with mechanistic target of rapamycin (mTOR) kinase signaling …

Macrophage metabolic plasticity enables repurposing of electron transport from energy
generation to inflammation and host defense. Altered respiratory complex II function has …

Nitric oxide (NO) has been known for many years to bind to cytochrome C oxidase, the
terminal acceptor in the mitochondrial electron transport chain, in competition with oxygen …

Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …

Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of
increased glycolysis triggered by insufficient oxygen supply to tissues. Macrophages are …

In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate
glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte …