The unique chemistry of oxygen has been both a resource and threat for life on Earth for at
least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more …

Human and mammalian thioredoxin reductases are selenoproteins containing an essential
catalytically active selenocysteine (Sec) residue. In contrast to the enzymes from bacteria …

Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

The importance of selenium as an essential trace element is now well recognized. In
proteins, the redox-active selenium moiety is incorporated as selenocysteine (Sec), the 21st …

This editorial shortly summarizes the highlights described in the Forum, novelties about
selenoproteins. Two articles describe the selenoprotein biosynthesis and the role of so far …

In the context of defense against pro-oxidants, selenium and the glutathione (GSH) system
play key functions. Major roles of GSH include direct interception of pro-oxidants, as well as …

The beneficial role of the trace element selenium (Se) in human health has been known for
several decades and is attributed both to low-molecular-weight Se compounds and to its …

Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …

Several decades after the discovery of selenium as an essential trace element in vertebrates
approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the …