Most current drug screening assays used to identify new drug candidates are 2D cell-based
systems, even though such in vitro assays do not adequately re-create the in vivo complexity …

Performing drug screening of tissue derived from cancer patient biopsies using
physiologically relevant 3D tumour models presents challenges due to the limited amount of …

Cell-based high throughput drug screening accelerates the pace of drug discovery which is
routinely operated on planar high-density multi-well plates with sophisticated robotic liquid …

Abstract 3D organotypic culture models such as organoids and multicellular tumor spheroids
(MCTS) are becoming more widely used for drug discovery and toxicology screening. As a …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …

The assessment of drug-dose responses is vital for the prediction of unwanted toxicological
effects in modern medicine. Three-dimensional (3D) cell cultures techniques can provide in …

The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Simple Summary Cancer is a global public health issue. The development and use of in vitro
cellular models with pre-clinical animal models are essential to elucidate the complex …