Long non-coding RNAs in the regulation of gene expression: physiology and disease

JCR Fernandes, SM Acuña, JI Aoki, LM Floeter-Winter… - Non-coding RNA, 2019 - mdpi.com
The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

The how and why of lncRNA function: an innate immune perspective

EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Immunobiology of long noncoding RNAs

MK Atianand, DR Caffrey… - Annual review of …, 2017 - annualreviews.org
The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene
regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that …

Long non-coding RNAs in innate and adaptive immunity

TM Aune, CF Spurlock III - Virus research, 2016 - Elsevier
Long noncoding RNAs (lncRNAs) represent a newly discovered class of regulatory
molecules that impact a variety of biological processes in cells and organ systems. In …

Long noncoding RNAs in host–pathogen interactions

F Agliano, VA Rathinam, AE Medvedev, SK Vanaja… - Trends in …, 2019 - cell.com
Long noncoding RNAs (lncRNAs) are key molecules that regulate gene expression in a
variety of organisms. LncRNAs can drive different transcriptional and post-transcriptional …

Long noncoding RNAs: insights from biological features and functions to diseases

X Li, Z Wu, X Fu, W Han - Medicinal research reviews, 2013 - Wiley Online Library
Over the past decade, genome‐wide transcriptomic studies have shown that the mammalian
genome is pervasively transcribed and produces many thousands of transcriptomes without …

Long non-coding RNAs and control of gene expression in the immune system

MK Atianand, KA Fitzgerald - Trends in molecular medicine, 2014 - cell.com
All cells of the immune system rely on a highly integrated and dynamic gene expression
program that is controlled by both transcriptional and post-transcriptional mechanisms …

Long non-coding RNAs in the regulation of the immune response

JA Heward, MA Lindsay - Trends in immunology, 2014 - cell.com
It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological
responses, and that they do so by a diverse range of mechanisms. In the field of …

[HTML][HTML] Long non-coding RNAs: Mechanism of action and functional utility

SA Bhat, SM Ahmad, PT Mumtaz, AA Malik… - Non-coding RNA …, 2016 - Elsevier
Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …

Control of immune cell homeostasis and function by lncRNAs

WK Mowel, JJ Kotzin, SJ McCright, VD Neal… - Trends in …, 2018 - cell.com
The immune system is composed of diverse cell types that coordinate responses to infection
and maintain tissue homeostasis. In each of these cells, extracellular cues determine highly …