The epithelial–mesenchymal transition (EMT) is a highly networked cellular process which
involves cell transition from the immotile epithelial to the motile mesenchymal phenotype …

Non‑small cell lung cancer (NSCLC) is one of the most devastating cancer types, accounting
for> 80% of lung cancer cases. The median relative survival time of patients with NSCLC is< …

Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …

Distant metastasis and local recurrence are still the major causes for failure of treatment in
patients with ovarian carcinoma (OC), making it urgent to further elicit the molecular …

Abstract Sirtuin1 (SIRT1) is a mammalian NAD+-dependent type III deacetylase that plays
paramount roles in diverse cellular processes. The nucleocytoplasmic shuttling of SIRT1 …

Melanoma is highly metastatic, and understanding of its molecular mechanism is urgently
needed for the development of therapeutic targets and prognostic assessment for metastatic …

Pulmonary metastasis is the leading cause of mortality in patients with osteosarcoma;
however, the underlying mechanism remains unclear. The NAD+-dependent deacetylase …

SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating
histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

SIRT1 plays an important role in human malignant progression, inducing cancer cell
proliferation and metastasis by regulating downstream gene expressions. However, little is …