Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …

Abstract Single-cell RNA-Seq (scRNA-Seq) enables the systematic molecular
characterization of heterogeneous tissues at an unprecedented resolution and scale …

Large-scale single-cell RNA sequencing (scRNA-seq) studies that profile hundreds of
thousands of cells are becoming increasingly common, overwhelming existing analysis …

Dysregulated cell-cell communication is a hallmark of many disease phenotypes. Due to
recent advances in single-cell transcriptomics and computational approaches, it is now …

Single-cell transcriptomics has transformed our ability to characterize cell states, but deep
biological understanding requires more than a taxonomic listing of clusters. As new methods …

Genome-wide association studies (GWAS) provide a powerful means to identify loci and
genes contributing to disease, but in many cases the related cell types/states through which …

Single-cell RNA sequencing (scRNA-seq) technology has significantly advanced our
understanding of the diversity of cells and how this diversity is implicated in diseases. Yet …

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …

Hundreds of millions of single cells have been analyzed to date using high throughput
transcriptomic methods, thanks to technological advances driving the increasingly rapid …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …