Inflammatory bowel disease: is it a primary immunodeficiency?

E Glocker, B Grimbacher - Cellular and Molecular Life Sciences, 2012 - Springer
Inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease are
chronic and relapsing conditions, characterized by abdominal pain, diarrhea, bleeding and …

[HTML][HTML] Intestinal immunoregulation: lessons from human mendelian diseases

F Charbit-Henrion, M Parlato, G Malamut… - Mucosal …, 2021 - Elsevier
The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut
surface to multiple environmental antigens and to billions of microbes have been scrutinized …

Early‐onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms

J Pazmandi, A Kalinichenko, RC Ardy… - Immunological …, 2019 - Wiley Online Library
Rare, monogenetic diseases present unique models to dissect gene functions and
biological pathways, concomitantly enhancing our understanding of the etiology of complex …

Immunopathophysiology of inflammatory bowel disease: how genetics link barrier dysfunction and innate immunity to inflammation

M Mehta, S Ahmed, G Dryden - Innate immunity, 2017 - journals.sagepub.com
Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic or relapsing immune activation and corresponding inflammation within the …

Inflammatory bowel disease: is the intestine a Trojan horse?

C Basset, J Holton - Science progress, 2002 - journals.sagepub.com
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the
intestines that is clinically heterogenous. The cause (s) of IBD are currently unknown but the …

Intestinal Immune Imbalance is an Alarm in the Development of IBD

C Hu, S Liao, L Lv, C Li, Z Mei - Mediators of inflammation, 2023 - Wiley Online Library
Immune regulation plays a crucial role in human health and disease. Inflammatory bowel
disease (IBD) is a chronic relapse bowel disease with an increasing incidence worldwide …

Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease

S Danese - … Journal of Physiology-Gastrointestinal and Liver …, 2011 - journals.physiology.org
Inflammatory bowel disease (IBD) pathogenesis is driven by the interactions between the
innate and the adaptive immune system. Both systems are actually expressed not only by …

Mechanisms of disease: inflammatory bowel diseases

GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

Monogenic intestinal epithelium defects and the development of inflammatory bowel disease

G Leung, AM Muise - Physiology, 2018 - journals.physiology.org
The incidence of inflammatory bowel disease (IBD) is increasing worldwide, most notably in
young children. The development of disease is a combination of several factors, including …

Immune aspects of the pathogenesis of inflammatory bowel disease

T Hisamatsu, T Kanai, Y Mikami, K Yoneno… - Pharmacology & …, 2013 - Elsevier
Although the precise etiologies of inflammatory bowel disease (IBD)(ulcerative colitis and
Crohn's disease) remain obscure, several reports have indicated that dysfunction of the …