Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Understanding the mechanisms that regulate skeletal muscle mass has remained a focus of
numerous researchers for many years. Recent investigations have begun to elucidate …

Growth and maintenance of skeletal muscle mass is critical for long-term health and quality
of life. Skeletal muscle is a highly adaptable tissue with well-known sensitivities to …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Non‐Technical Summary Chronic mechanical loading (CML) of skeletal muscle induces
growth and this effect can be blocked by the drug rapamycin. Rapamycin is considered to be …

Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process.
Despite substantial advances, we are far from understanding exactly how muscle …

Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

Non‐technical summary Hypertrophy of skeletal muscle in response to resistance exercise
is associated with significantly elevated rates of protein synthesis. The protein kinase …

Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle
atrophy of aging and disease, or to improve athletic performance. While this desired muscle …

Delineating the molecular mechanisms that are responsive to work overload is crucial to
understanding the adaptive processes controlling skeletal muscle mass. We have examined …