HIV-1 integrase (IN) mediates the insertion of viral cDNA into the cell genome, a vital
process for replication. This step is catalyzed by two separate DNA reaction events, termed …

Background The 18 residue tail abutting the SH3 fold that comprises the heart of the C-
terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology …

We have recently reported that a recombinant HIV-1NL4. 3 containing Met-to-Ile change at
codon 50 of integrase (IN)(IN: M50I) exhibits suppression of the virus release below 0.5% of …

There has been accumulating evidence for the involvement of retroviral integrase (IN) in the
reverse transcription of viral RNA. We previously identified a host factor, survival motor …

Integration of viral DNA into cellular DNA is an essential step in the replication cycle of HIV
and other retroviruses. The first antiviral drugs that target integrase, the viral enzyme that …

HIV-1 integrase specifically recognizes and cleaves viral end DNA during the initial step of
retroviral integration. The protein and DNA determinants of the specificity of viral end DNA …

The retroviral protein Integrase (IN) catalyzes concerted integration of viral DNA into host
chromatin to establish a permanent infection in the target cell. We learned a great deal about …

During infection, human immunodeficiency virus type 1 integrase engages a number of
molecules and mechanisms, both of viral and cellular origin. In one of such instances …

Replication of HIV-1 requires the covalent integration of the viral cDNA into the host
chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the …

HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-
transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs …