Understanding of the structures and functions of the retroviral integrase (IN), a key enzyme
in the viral replication cycle, is essential for developing antiretroviral treatments and …

Recently, a new class of HIV-1 integrase (IN) inhibitors with a dual mode of action, called IN-
LEDGF/p75 allosteric inhibitors (INLAIs), was described. Designed to interfere with the IN …

HIV-1 integrase (IN) is an important target for contemporary antiretroviral drug design
research. Historically, efforts at inactivating the enzyme have focused upon blocking its …

The viral integrase (IN) protein is the only viral protein known to be required for integration of
the human immunodeficiency virus type 1 (HIV-1) genome into the host cell DNA, a step in …

Retroviral integrase is a multimeric enzyme that catalyzes the integration of reverse-
transcribed viral DNA into the cellular genome. Beyond integration, the Human …

ABSTRACT MK-2048 represents a prototype second-generation integrase strand transfer
inhibitor (INSTI) developed with the goal of retaining activity against viruses containing …

Results of in vitro assays identified residues in the C-terminal domain (CTD) of human
immunodeficiency virus type 1 (HIV-1) integrase (IN) important for IN-IN and IN-DNA …

Previous biochemical and genetic evidence indicated that the functional form of retroviral
integrase protein (IN) is a multimer. A direct demonstration of IN oligomerization during the …

The central function of the retroviral integrase protein (IN) is to catalyze the integration of
viral DNA into the host genome to form the provirus. The IN protein has also been reported …

Retroviruses favor target-DNA (tDNA) distortion and particular bases at sites of integration,
but the mechanism underlying HIV-1 selectivity is unknown. Crystal structures revealed a …