Biomedical studies by TOF-SIMS imaging

C Bich, D Touboul, A Brunelle - Biointerphases, 2015 - pubs.aip.org
Imaging by secondary ion mass spectrometry coupled to time-of-flight mass analysis (TOF-
SIMS) is a method of which the applications have greatly increased since 10 years. Taking …

Biological tissue sample preparation for time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging

S Yoon, TG Lee - Nano Convergence, 2018 - Springer
Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …

Lipid imaging with cluster time-of-flight secondary ion mass spectrometry

A Brunelle, O Laprévote - Analytical and bioanalytical chemistry, 2009 - Springer
This brief article provides an overview of the current state of the art in biological imaging
mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF …

Recent advances in biological tissue imaging with time-of-flight secondary ion mass spectrometry: polyatomic ion sources, sample preparation, and applications

A Brunelle, O Laprevote - Current pharmaceutical design, 2007 - ingentaconnect.com
Recent technological and methodological improvements have greatly enhanced the
sensitivity of the Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS), thus making …

A new dynamic in mass spectral imaging of single biological cells

JS Fletcher, S Rabbani, A Henderson… - Analytical …, 2008 - ACS Publications
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has unique capabilities in the
area of high-resolution mass spectrometric imaging of biological samples. The technique …

Cluster TOF‐SIMS imaging as a tool for micrometric histology of lipids in tissue

C Bich, D Touboul, A Brunelle - Mass spectrometry reviews, 2014 - Wiley Online Library
Recent developments in instrumentation, ion beams or analyzers, for cluster time‐of‐flight
secondary ion mass spectrometry (TOF‐SIMS) imaging are described here. The methods …

Cluster TOF‐SIMS imaging and the characterization of biological materials

J Vickerman, N Winograd - Cluster Secondary Ion Mass …, 2013 - Wiley Online Library
This chapter seeks to provide a brief overview of the present capabilities and the future
possibilities of time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) using cluster …

Biological tissue imaging with a hybrid cluster SIMS quadrupole time-of-flight mass spectrometer

A Carado, J Kozole, M Passarelli, N Winograd… - Applied Surface …, 2008 - Elsevier
A 20keV C60+ ion source was mounted onto a commercial MALDI/electrospray orthogonal
ToF mass spectrometer. Cross-sectional mouse brain and lung slices between 5 and 10μm …

TOF-SIMS imaging of biological tissue sections and structural determination using tandem MS

S Van Nuffel, A Brunelle - Mass Spectrometry Imaging of Small Molecules …, 2022 - Springer
Over the past couple of years, imaging mass spectrometry (IMS) has arisen as a powerful
tool to answer research questions in the biomedical field. Imaging mass spectrometry allows …

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

P Massonnet, RMA Heeren - Journal of Analytical Atomic Spectrometry, 2019 - pubs.rsc.org
This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …