Porphyromonas gingivalis Fimbriae Use β2Integrin (CD11/CD18) on Mouse Peritoneal Macrophages as a Cellular Receptor, and the CD18 β Chain Plays a …

A Takeshita, Y Murakami, Y Yamashita… - Infection and …, 1998 - Am Soc Microbiol
In this study, we demonstrate that Porphyromonas gingivalis fimbriae use molecules of β2
integrin (CD11/CD18) on mouse peritoneal macrophages as cellular receptors and also …

Porphyromonas gingivalis Fimbriae Proactively Modulate β2 Integrin Adhesive Activity and Promote Binding to and Internalization by Macrophages

G Hajishengallis, M Wang, E Harokopakis… - Infection and …, 2006 - Am Soc Microbiol
In monocytes, the fimbriae of the oral pathogen Porphyromonas gingivalis activate cross talk
signaling from Toll-like receptor 2 (TLR2) to the β2 integrin CD11b/CD18, leading to the …

[HTML][HTML] Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins

I Nakagawa, A Amano, H Inaba, S Kawai… - Microbes and …, 2005 - Elsevier
Porphyromonas gingivalis is a predominant periodontal pathogen, whose fimbriae are
considered to be a major virulence factor, especially for bacterial adherence and invasion of …

Cytokine production induced by a 67‐kDa fimbrial protein from Porphyromonas gingivalis

N Hamada, K Watanabe, M Arai… - Oral microbiology …, 2002 - Wiley Online Library
Fimbriae have been reported to play an important role in the adherence of Porphyromonas
gingivalis to oral surfaces and possibly in triggering host responses. P. gingivalis ATCC …

Molecular Interaction of Porphyromonas gingivalis with Host Cells: Implication for the Microbial Pathogenesis of Periodontal Disease

A Amano - Journal of periodontology, 2003 - Wiley Online Library
Porphyromonas gingivalis is a predominant periodontal pathogen, which expresses a
number of potential virulence factors involved in the pathogenesis of periodontitis. Among …

Porphyromonas gingivalis fimbrillin is one of the fibronectin-binding proteins

Y Murakami, H Iwahashi, H Yasuda… - Infection and …, 1996 - Am Soc Microbiol
In this study, we demonstrate that Porphyromonas gingivalis fimbrillin, a major component of
bacterial fimbriae, is one of the fibronectin-binding proteins and that fibronectin is a potent …

Involvement of integrins in fimbriae‐mediated binding and invasion by Porphyromonas gingivalis

Ö Yilmaz, K Watanabe, RJ Lamont - Cellular microbiology, 2002 - Wiley Online Library
Interaction between the major fimbriae of Porphyromonas gingivalis and gingival epithelial
cells is important for bacterial adhesion and invasion. In this study, we identified integrins as …

Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype

T Kato, S Kawai, K Nakano, H Inaba… - Cellular …, 2007 - Wiley Online Library
Porphyromonas gingivalis is a periodontal pathogen whose fimbriae are classified into six
genotypes based on the diversity of the fimA genes encoding each fimbria subunit. It was …

Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors

T Ogawa, Y Asai, M Hashimoto… - European journal of …, 2002 - Wiley Online Library
Bacterial fimbriae are associated with a specific adherence factor, adhesin, in their microbial
etiology. Porphyromonas gingivalis, as an anaerobic Gram‐negative periodontopathogenic …

Porphyromonas gingivalis fimbriae‐dependent interleukin‐6 autocrine regulation by increase of gp130 in endothelial cells

YS Ho, MT Lai, SJ Liu, CT Lin… - Journal of …, 2009 - Wiley Online Library
Background and Objective: Local persistent infection by Porphyromonas gingivalis leads to
inflammatory systemic diseases, such as atherosclerosis. We have reported previously that …