[HTML][HTML] Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors

G Hajishengallis, P Ratti, E Harokopakis - Journal of Biological Chemistry, 2005 - ASBMB
The fimbriae of the oral pathogen Porphyromonas gingivalis induce Toll-like receptor 2
(TLR2)-dependent macrophage activation upon their recognition by CD14 and the β 2 …

Bacteroides (Porphyromonas) gingivalis fimbriae activate mouse peritoneal macrophages and induce gene expression and production of interleukin-1

S Hanazawa, Y Murakami, K Hirose… - Infection and …, 1991 - Am Soc Microbiol
The purpose of this study was to examine whether Bacteroides (Porphyromonas) gingivalis
fimbriae, an important structure involved in attachment of the bacteria to periodontal tissues …

Requirement for Intercellular Adhesion Molecule 1 and Caveolae in Invasion of Human Oral Epithelial Cells by Porphyromonas gingivalis

R Tamai, Y Asai, T Ogawa - Infection and immunity, 2005 - Am Soc Microbiol
Porphyromonas gingivalis, a periodontopathic bacterium, is known to invade oral epithelial
cells in periodontal lesions, although the mechanism is unclear. In the present study, goat …

Soluble CD14‐Dependent Intercellular Adhesion Molecule‐1 Induction by Porphyromonas gingivalis Lipopolysaccharide in Human Gingival Fibroblasts

T Masaka, J Hayashi, I Ishikawa - Journal of periodontology, 1999 - Wiley Online Library
Background: Intercellular adhesion molecule‐1 (ICAM‐1) is involved in the accumulation
and activation of leukocytes in inflammatory sites through binding to β2 integrins expressed …

Porphyromonas gingivalis 67-kDa fimbriae induced cytokine production and osteoclast differentiation utilizing TLR2

H Hiramine, K Watanabe, N Hamada… - FEMS microbiology …, 2003 - academic.oup.com
Porphyromonas gingivalis, a major etiological agent of adult periodontitis, has two distinctly
different types of fimbriae on the cell surface. The major fimbriae, which consist of a 41-kDa …

Fibronectin in saliva inhibits Porphyromonas gingivalis fimbria-induced expression of inflammatory cytokine gene in mouse macrophages

Y Murakami, S Hanazawa, S Tanaka… - FEMS Immunology & …, 1998 - academic.oup.com
The aim of this study was to examine whether fibronectin in saliva plays a regulatory role in
Porphyromonas gingivalis fimbria-mediated pathogenesis in adult periodontal disease. Our …

Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2

Y Aoki, K Tabeta, Y Murakami, F Yoshimura… - Biochemical and …, 2010 - Elsevier
Bacterial fimbriae are an important pathogenic factor. It has been demonstrated that fimbrial
protein encoded by fimA gene (FimA fimbriae) of Porphyromonas gingivalis not only …

Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll‐like receptor 2, and phosphatidylinositol‐3‐kinase

E Harokopakis, G Hajishengallis - European journal of …, 2005 - Wiley Online Library
CD11b–CD18 and other integrins play important roles in immunity and inflammation and
require prior activation through inside‐out signaling to efficiently bind their ligands. We …

Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis

DT Graves, G Naguib, H Lu… - Journal of endotoxin …, 2005 - journals.sagepub.com
The fimA gene encodes the major fimbrial protein of Porphyromonas gingivalis. It has been
shown to stimulate adhesion to salivary proteins and other bacteria. It is also thought to play …

[HTML][HTML] Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors

Y Takayanagi, T Kikuchi, Y Hasegawa, Y Naiki… - Journal of Clinical …, 2020 - mdpi.com
Porphyromonas gingivalis Mfa1 fimbriae are thought to act as adhesion factors and to direct
periodontal tissue destruction but their immunomodulatory actions are poorly understood …