Porphyromonas gingivalis mediates the shedding and proteolysis of complement regulatory protein CD46 expressed by oral epithelial cells

H Mahtout, F Chandad, JM Rojo… - Oral Microbiology and …, 2009 - Wiley Online Library
Introduction: Human cells express membrane‐bound complement regulatory proteins to
prevent complement‐mediated autologous tissue damage. In this study, we hypothesized …

Gingipains are the important virulence factors of Porphyromonas gingivalis downregulating B10 cells

H Zou, N Zhou, X Cheng, Y Qiu… - Molecular Oral …, 2023 - Wiley Online Library
Porphyromonas gingivalis is a keystone pathogen in periodontitis. Our previous study
indicated that periodontitis induced by P. gingivalis increased the percentage of CD19+ B …

Recombinant fimbriae protein of Porphyromonas gingivalis induces an inflammatory response via the TLR4/NF‑κB signaling pathway in human peripheral blood …

J Cai, J Chen, H Guo, Y Pan… - International …, 2019 - spandidos-publications.com
Porphyromonas gingivalis (P. gingivalis) is a periodontal pathogen that may accumulate
with other organisms in subgingival plaque biofilms and is associated with periodontal …

Fimbria-Dependent Activation of Cell Adhesion Molecule Expression in Porphyromonas gingivalis-Infected Endothelial Cells

M Khlgatian, H Nassar, HH Chou… - Infection and …, 2002 - Am Soc Microbiol
Porphyromonas gingivalis is an oral pathogen that has recently been associated with
chronic inflammatory diseases such as atherosclerosis. The strength of the epidemiological …

Identification of murine protective epitopes on the Porphyromonas gingivalis fimbrillin molecule

M Deslauriers, S Haque, PM Flood - Infection and immunity, 1996 - Am Soc Microbiol
Fimbriae from Porphyromonas gingivalis are believed to play an important role in the
pathogenesis of periodontal diseases. The aim of the present study was to identify the …

Cytokine Profiling of Macrophages Exposed to Porphyromonas gingivalis, Its Lipopolysaccharide, or Its FimA Protein

Q Zhou, T Desta, M Fenton, DT Graves… - Infection and …, 2005 - Am Soc Microbiol
To characterize the roles of Porphyromonas gingivalis and its components in the disease
processes, we investigated the cytokine profile induced by live P. gingivalis, its …

Construction of a sIgA-enhancing anti-Porphyromonas gingivalis FimA vaccine and nasal immunization in mice

H Guo, X Wang, G Jiang, P Yang - Immunology letters, 2006 - Elsevier
Porphyromonas gingivalis is implicated in the etiology of chronic periodontitis. Fimbriae are
one of several critical surface virulence factors of P. gingivalis. Interleukin 15 (IL-15) is a …

Differential Activation of Human Gingival Epithelial Cells and Monocytes by Porphyromonas gingivalis Fimbriae

MA Eskan, G Hajishengallis, DF Kinane - Infection and immunity, 2007 - Am Soc Microbiol
Humans develop periodontitis in response to challenge by microbial dental plaque.
Inflammation begins after perturbation of gingival epithelial cells by subgingival bacteria …

Mechanism and implications of CXCR4‐mediated integrin activation by Porphyromonas gingivalis

G Hajishengallis, ML McIntosh… - Molecular oral …, 2013 - Wiley Online Library
In monocytes and macrophages, the interaction of Porphyromonas gingivalis with Toll‐like
receptor 2 (TLR 2) leads to the activation of a MyD88‐dependent antimicrobial pathway and …

A peptide, ALTTE, within the fimbrial subunit protein from Porphyromonas gingivalis, induces production of interleukin 6, gene expression and protein …

T Ogawa, H Uchida - FEMS Immunology & Medical Microbiology, 1995 - academic.oup.com
Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69–
73 (ALTTE) of the fimbrial subunit protein, FP381 (69–73), function in the induction of …